In simple words, the bill wants all government bosses to make a safety plan to keep workers safe if there's a big, country-wide sickness like a pandemic. This means making sure there's enough protection, telling people if someone got sick, cleaning things, and letting people work from home when needed.

S. 5279 is like a big rule book telling government offices how to keep everyone safe during times when a big sickness is spreading. It makes sure they have safety plans with masks, cleaning, and testing, and lets people know where to find these plans and who to tell if there's a problem.